COWDENS DISEASE (MULTIPLE HAMARTOMA SYNDROME)

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 56  (3) , 179-184
Abstract
Cutaneous and oral lesions appearing as verrucous papules are a regular and diagnostic finding in Cowden''s disease. The lesions occur predominantly over the central portion of the face, concentrated around orifices, lips, gingiva and tongue, and over the acral portions of the upper extremities. These skin lesions were associated with fibrocystic breast disease, carcinoma of the breast, thyroid tumors, ovarian cysts, gastrointestinal polyposis, fibromas angiomas and lipomas. It is important to be able to distinguish the skin lesions from simple verruca vulgaris because they serve as a cutaneous marker for existing or potential internal malignancy, especially of the breast and thyroid.

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