EXAMINATION OF THE ROLE OF NITRIC OXIDE SYNTHASE AND RENAL KALLIKREIN AS CANDIDATE GENES FOR ESSENTIAL HYPERTENSION
- 1 July 1996
- journal article
- clinical trial
- Published by Wiley in Clinical and Experimental Pharmacology and Physiology
- Vol. 23 (6-7) , 564-566
- https://doi.org/10.1111/j.1440-1681.1996.tb02780.x
Abstract
1. Nitric oxide synthase and renal kallikrein are both involved in blood pressure regulation. Genes for these enzymes may, therefore, be considered candidates for hypertension pathogenesis. 2. In the present study, genotypes for nitric oxide synthase and renal kallikrein microsatellite markers were determined in a cross-sectional association analysis of hypertensive patients and normotensive control subjects. 3. Results from this study did not indicate an association of either of the candidate gene polymorphisms with essential hypertension. Hence, findings for this study do not support a role for these genes in human hypertension.Keywords
This publication has 16 references indexed in Scilit:
- Hypertension in mice lacking the gene for endothelial nitric oxide synthaseNature, 1995
- Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat.Journal of Clinical Investigation, 1995
- Monte Carlo tests for associations between disease and alleles at highly polymorphic lociAnnals of Human Genetics, 1995
- Gene Structure, Polymorphism and Mapping of the Human Endothelial Nitric Oxide Synthase GeneBiochemical and Biophysical Research Communications, 1994
- Molecular Genetic Analyses of RFLPs for PCR-Amplified Growth Hormone Gene, Renal Kallikrein Gene and Atrial Natriuretic Factor Gene in Essential Hypertension.Hypertension Research, 1993
- Molecular basis of human hypertension: Role of angiotensinogenCell, 1992
- Association of a RFLP for the insulin receptor gene, but not insulin, with essential hypertensionBiochemical and Biophysical Research Communications, 1991
- Human glandular kallikrein genes: Genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR markerGenomics, 1991
- A gene for high urinary kallikrein may protect against hypertension in Utah kindreds.Hypertension, 1989
- Human Kidney Kallikrein: cDNA Cloning and Sequence AnalysisDNA, 1985