β-CIT SPECT demonstrates reduced availability of serotonin transporters in patients with Fatal Familial Insomnia
- 1 July 2002
- journal article
- case report
- Published by Springer Nature in Journal Of Neural Transmission-Parkinsons Disease and Dementia Section
- Vol. 109 (7-8) , 1105-1110
- https://doi.org/10.1007/s007020200093
Abstract
Fatal familial insomnia (FFI) is a rare hereditary human prion disease with unique clinical features including progressive sleep impairment and autonomic dysfunction. The serotonergic system is considered to be involved in the regulation of the sleep-wake cycle. In this study we demonstrate a reduced availability of serotonin transporters of 57% and 73% respectively in a thalamus-hypothalamus region of two FFI patients examined with beta-CIT SPECT as compared to age-expected control values.Keywords
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