THE EFFECT OF ANTILYMPHOCYTIC ANTIBODY ON THE PRIMARY IMMUNE RESPONSE OF MICE TO SHEEP ERYTHROCYTES, BOVINE SERUM ALBUMIN, AND TYPE III PNEUMOCOCCUS POLYSACCHARIDE

1 August 1971

journal article
Published by Wolters Kluwer Health in Transplantation

Vol. 12 (2) , 109-113
https://doi.org/10.1097/00007890-197108000-00002

Abstract

The effect of antilymphocytic antibody on the primary immune response to sheep erythrocytes, alum-precipitated bovine serum albumin (BSA), and type III pneumococcus polysaccharide has been investigated in CBA/Ca, C3H/He, and A/HeJ strain mice. This material caused a highly significant suppression of the primary immune response to sheep erythrocytes and BSA in all three mouse strains. Its effect on the primary immune response to type III polysaccharide was less dramatic but, nevertheless, it significantly suppressed this response in CBA mice, indicating that our antilymphocytic antibody preparation did not readily discriminate between thymus-dependent and -independent humoral immune responses in this strain of mice.

Keywords

This publication has 0 references indexed in Scilit: