Fusicoccin. Part 6. Biosynthesis of fusicoccin from [3-13C]- and (4R)-[4-3H1]-mevalonic acid
- 1 January 1976
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 20,p. 2221-2228
- https://doi.org/10.1039/p19760002221
Abstract
[3-13C]Mevalonic acid lactone has been synthesised from [1-13C]acetate and selectively incorporated into positions 3,7,11,15, and 24 of fusicoccin (1a). Four out of a possible five 4-pro-R mevalonoid hydrogen atoms were retained in fusicoccin and fusicoccin J, and three were retained in fusicoccin H. The results are consistent with the cyclisation of a polyprenyl pyrophosphate precursor in a manner different to that previously observed in the biosynthesis of the ophiobolins.This publication has 0 references indexed in Scilit: