Mycobacteria and Lymphoreticular Tumours in Xenopus Iaevis, the South African Clawed Toad

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Abstract
Bacteria isolated from Xenopus lymphoreticular tumour cells were cultured and identified as Mycobacterium marinum, a well-known opportunistic pathogen. Large doses of the cultured bacteria induced granulomata in Xenopus toadlets. Lymphoreticular tumours were not induced either by lethal or sub-lethal doses of M. marinum, or by cell-free preparations made from the bacteria or from bacterium-infected cell cultures. These results suggest that the presence of mycobacteria is a secondary result and not, as has been suggested by others, a primary cause of lymphoreticular tumour lesions in Xenopus.

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