Template-directed synthesis on short oligoribocytidylates
- 1 December 1986
- journal article
- research article
- Published by Springer Nature in Journal of Molecular Evolution
- Vol. 23 (4) , 287-289
- https://doi.org/10.1007/bf02100635
Abstract
The oligonucleotides C(pC)n, n=4, 5, 6, 7, are efficient templates for the oligomerization of guanosine-5′-phospho-2-methylimidazole (2-MeImpG). They yield oligomeric products that are substantially less regiospecific than those obtained on polycytidylate [poly(C)]. The overall distributions of products obtained on oligo(C)s are generally similar to those of products obtained on oligodeoxycytidylates [oligo(dC)s], but there are substantial differences in the ratios of isomers. The 3′–5′-linked dinucleoside monophosphate GpG efficiently initiates oligomer formation with 2-MeImpG on oligo(C) templates. The pattern of products obtained by chain extension parallels closely that of products obtained directly from 2-MeImpG, except that the former products lack the 5′-terminal phosphate group.This publication has 4 references indexed in Scilit:
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- Non-enzymatic template-directed synthesis on RNA random copolymersJournal of Molecular Biology, 1984
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