CLINICAL EVALUATION OF INTRAVENOUS MINOCYCLINE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 15  (4) , 194-198
Abstract
Patients (24) with severe infections were treated with i.v. minocycline 100 mg every 12 h. Average blood levels were within therapeutic ranges during the 1st 12 h after the initial dose. Determination of efficacy of therapy in 23 of the patients who were evaluable showed that clinical and bacteriological results were satisfactory in 20 patients, unsatisfactory in 2 and questionable in 1. One patient developed a fatal secondary infection which may have been related to prior therapy with minocycline. No toxicities or side effects were observed.

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