Labeling of Polymer Nanostructures for Medical Imaging: Importance of Cross-Linking Extent, Spacer Length, and Charge Density
- 7 April 2007
- journal article
- Published by American Chemical Society (ACS) in Macromolecules
- Vol. 40 (9) , 2971-2973
- https://doi.org/10.1021/ma070267j
Abstract
Radiolabeling studies were employed to investigate the influence of structure on the efficiency of surface functionalization for poly(acrylic acid)-coated shell crosslinked nanoparticles (SCKs) with two types of amine-terminated DOTA chelators. An intricate interplay between the chemical and physical properties of both the DOTA derivative and the SCK nanostructures was revealed, demonstrating the importance of structural control.Keywords
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