Interleukin-1β, Transforming Growth Factor-β 1 , and Bradykinin Attenuate Cyclic AMP Production by Human Pulmonary Artery Smooth Muscle Cells in Response to Prostacyclin Analogues and Prostaglandin E 2 by Cyclooxygenase-2 Induction and Downregulation of Adenylyl Cyclase Isoforms 1, 2, and 4
- 20 February 2004
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 94 (3) , 353-361
- https://doi.org/10.1161/01.res.0000111801.48626.f4
Abstract
Increased levels of inflammatory cytokines contribute to the pathophysiology of pulmonary hypertension. Prostacyclin (PGI2) analogues, which relax pulmonary vessels mainly through cAMP elevation, h...Keywords
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