Biosynthesis of the diterpene antibiotic, aphidicolin, by radioisotope and 13C nuclear magnetic resonance methods
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 10,p. 389-391
- https://doi.org/10.1039/c39750000389
Abstract
Spectroscopic and degradative methods with 1,2-13C2-acetate and 2-14C-4R-3H-mevalonate precursors show that aphidicolin arises from initial chair-boat cyclization of the diterpene chain followed by successive H-shift, cyclization, and rearrangement steps.Keywords
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