In vitro activity of tosufloxacin (A-60969) and clarithromycin (A-56268, TE-031) against resistantHaemophilus influenzae, Streptococcus pneumoniae andBranhamella catarrhalis isolates

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Abstract
The activity of tosufloxacin (A-60969), a new oral quinolone, and clarithromycin (A-56268, TE-031), a new oral macrolide, was compared in vitro to that of other oral quinolones and beta-lactam antimicrobial agents against clinical isolates of ampicillin and/or chloramphenicol resistantHaemophilus influenzae, penicillin resistantStreptococcus pneumoniae and beta-lactamase producingBranhamella catarrhalis. Results were compared to those for sensitive isolates. Tosufloxacin was the most active compound againstHaemophilus influenzae and was more active than ciprofloxacin or ofloxacin against all strains ofStreptococcus pneumoniae. Tosufloxacin was also more active than any of the beta-lactam drugs tested against penicillin resistant or relatively penicillin resistant isolates. Clarithromycin was the most active compound tested against both penicillin sensitive and penicillin resistantStreptococcus pneumoniae, and was as active as ciprofloxacin againstBranhamella catarrhalis. In view of the favourable in vitro activity against common bacterial respiratory pathogens, tosufloxacin should be considered for clinical trials in adults with respiratory tract infections, while clarithromycin might be useful in treatment of infection with these organisms in all age groups.