Zinc Finger Protein Sall2 Is Not Essential for Embryonic and Kidney Development
Open Access
- 1 January 2003
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 23 (1) , 62-69
- https://doi.org/10.1128/mcb.23.1.62-69.2003
Abstract
SALL/Sall is a mammalian homolog of the Drosophila region-specific homeotic gene spalt (sal), and heterozygous mutations in SALL1 in humans lead to Townes-Brocks syndrome. We earlier reported that mice deficient in Sall1 die in the perinatal period and that kidney agenesis or severe dysgenesis are present. We have now generated mice lacking Sall2, another Sall family gene. Although Sall2 is expressed mostly in an overlapping fashion versus that of Sall1, Sall2-deficient mice show no apparent abnormal phenotypes. Morphology and gene expression patterns of the mutant kidney were not affected. Mice lacking both Sall1 and Sall2 show kidney phenotypes comparable to those of Sall1 knockout, thereby demonstrating the dispensable roles of Sall2 in embryonic and kidney development.Keywords
This publication has 25 references indexed in Scilit:
- SALL3, a New Member of the Human spalt-like Gene Family, Maps to 18q23Genomics, 1999
- Mutations in the SALL1 putative transcription factor gene cause Townes-Brocks syndromeNature Genetics, 1998
- Isolation, Characterization, and Organ-Specific Expression of Two Novel Human Zinc Finger Genes Related to theDrosophilaGenespaltGenomics, 1996
- Renal and neuronal abnormalities in mice lacking GDNFNature, 1996
- Defects in enteric innervation and kidney development in mice lacking GDNFNature, 1996
- Renal agenesis and the absence of enteric neurons in mice lacking GDNFNature, 1996
- Direct and Long-Range Action of a DPP Morphogen GradientCell, 1996
- A gene complex acting downstream of dpp in Drosophila wing morphogenesisNature, 1996
- Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4Nature, 1994
- Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor RetNature, 1994