New modified substrates for discriminating between human DNA polymerases α and ϵ
- 2 January 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 357 (1) , 23-26
- https://doi.org/10.1016/0014-5793(94)01319-v
Abstract
Two 2′-deoxynucleoside 5′-α-methylenephosphonyl-β,γ-diphosphates were synthesized. They were incorporated into the DNA chain by DNA polymerase α from human placenta. Meanwhile, they were not recognized by DNA polymerases ϵ and β of the same origin as well as by reverse transcriptases from human immunodeficiency virus and avian myeloblastosis virusKeywords
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