Increase of Whole-Body Calcium and Skeletal Mass in Normal and Osteoporotic Adult Rats Treated with Parathyroid Hormone

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Abstract
The effect of long-term administration of parathyroid hormone (PTH) on whole-body Ca and ash weight of individual bones was studied in normal and osteoporotic adult female rats in order to examine whether such a treatment could induce a positive Ca balance. Osteoporosis was induced by Ca restriction during pregnancy and lactation. Sequential measurements of whole-body Ca were made by neutron activation. In non-osteoporotic intact and thyroparathyroidectomized rats a daily dose of 75 U of human PTH 1-34 given s.c. for 3 wk increased whole-body Ca. In osteoporotic animals 25-50 U of either bovine PTH 1-84 or human PTH 1-34 given s.c. twice daily for 6 wk increased both whole-body Ca and ash weight of individual bones. Microradiographic examination of the tibiae indicates, however, that PTH administration does not result in the restoration of individual trabeculae lost during the development of osteoporosis. PTH can enhance skeletal mass in both normal and osteoporotic rats. In osteoporotic animals the restoration of whole-body Ca and ash weight of individual bones is not accompanied by a return of the morphological structure of the tibia to normal.

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