Urinary and faecal excretion of chrysene and chrysene metabolites by rats after oral, intraperitoneal, intratracheal or intrapulmonary application
- 1 January 1988
- journal article
- research article
- Published by Springer Nature in Archives of Toxicology
- Vol. 62 (6) , 401-405
- https://doi.org/10.1007/bf00288341
Abstract
The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of administration. In all cases the oxidation of chrysene in the 1,2- or 3,4-position predominates, whereas oxidation in the 5,6-position (K-region) seems be a minor pathway.Keywords
This publication has 21 references indexed in Scilit:
- Comparison of chrysene metabolism in epithelial human bronchial and Syrian hamster lung cellsCancer Letters, 1987
- Monooxygenase induction by various xenobiotics and its influence on rat liver microsomal metabolism of chrysene in comparison to benz[a]anthraceneCancer Letters, 1987
- Determination of hydroxylated metabolites of polycyclic aromatic hydrocarbons in urineJournal of Chromatography B: Biomedical Sciences and Applications, 1987
- The formation of 9-hydroxychrysene-l,2-diol as an intermediate in the metabolic activation of chryseneCarcinogenesis: Integrative Cancer Research, 1985
- Metabolic activation of chrysene in mouse skin: evidence for involvement of a triol-epoxideCarcinogenesis: Integrative Cancer Research, 1983
- Metabolic conversion of dibenz[a,h]anthracene (+/-)trans-1,2-dihydrodiol and chrysene (+/-)trans-3,4-dihydrodiol to vicinal dihydrodiol epoxides.Proceedings of the National Academy of Sciences, 1981
- The metabolism of a series of polycyclic hydrocarbons by mouse skin maintained in short-term organ cultureChemico-Biological Interactions, 1980
- Epoxides in Polycyclic Aromatic Hydrocarbon Metabolism and CarcinogenesisAdvances in Cancer Research, 1974
- Qualitative and quantitative studies on the metabolism of a series of aromatic hydrocarbons by rat-liver preparationsBiochemical Pharmacology, 1970
- The metabolism of chrysene: the isolation of 3-methoxychrysene by methylation of the phenolic metabolite of chrysene from rat faecesBiochemical Journal, 1949