Aldosterone in vitro restores nephron Na?K-ATPase of distal segments from adrenalectomized rabbits
- 1 April 1980
- journal article
- research article
- Published by Springer Nature in Pflügers Archiv - European Journal of Physiology
- Vol. 384 (3) , 203-206
- https://doi.org/10.1007/bf00584554
Abstract
Aldosterone, when added in vitro to defined nephron segments, dissected from adrenalectomized rabbits, restores the depressed Na+−K+-ATPase activity in the thick ascending limb of the loop of Henle and in the cortical collecting tubule within 1 h of incubation. The direct effect is specific and, as demonstrated for the cortical collecting tubule, dose-dependent. The time course of aldosterone-mediated Na+−K+-ATPase activation is compatible with the conjecture of changes in the enzyme lipid environment.This publication has 13 references indexed in Scilit:
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