A Mutant for Spontaneous Seizures in C57BL/10Bg Mice
- 1 February 1983
- Vol. 24 (1) , 15-24
- https://doi.org/10.1111/j.1528-1157.1983.tb04861.x
Abstract
The symptomatology, EEG and other correlates, development and genetics of a new mutant in mice for spontaneous seizures are described. This recessive mutant is designated spontaneous seizures and is assigned the gene symbol sps. Just at or after puberty, 25% of the sps/sps homozygotes show behavioral arrest and spontaneous generalized convulsions. The behavioral arrest is associated with 1-2/s high-voltage spikes in the neocortex and the generalized convulsions are associated with paroxysmal activity in the neocortex. The effects of this mutant are compared with those of others for reflex or spontaneous seizures in mice.Keywords
This publication has 12 references indexed in Scilit:
- Spontaneous polyspike discharges in an epileptic mutant mouse (tottering)Experimental Neurology, 1979
- Genetically determined spontaneous and pentylenetetrazol-induced brief spindle episodes in miceExperimental Neurology, 1979
- Epileptiform mice, a new neurological mutantJournal of Heredity, 1979
- Inherited Epilepsy: Spike-Wave and Focal Motor Seizures in the Mutant Mouse TotteringScience, 1979
- Pharmacogenetic differences in audiogenic seizure priming of C57BL/6Bg and DBA/1Bg-asr micePharmacology Biochemistry and Behavior, 1977
- Brain ?-Aminobutyric acid and acoustic priming in C57BL/6Bg micePsychopharmacology, 1977
- Electroencephalographic correlates of the audiogenic seizure response of inbred micePhysiology & Behavior, 1976
- The development of convulsive seizures in the grasshopper mouse (Onychomys torridus)Developmental Psychobiology, 1975
- The Gerbil as a Model for the Study of the EpilepsiesEpilepsia, 1974
- Catalog of the Neurological Mutants of the MousePublished by Harvard University Press ,1965