GLYCOGEN ACCUMULATION IN ALVEOLAR TYPE-II CELLS IN 3-METHYLINDOLE-INDUCED PULMONARY-EDEMA IN GOATS

  • 1 January 1981
    • journal article
    • research article
    • Vol. 105  (3) , 255-263
Abstract
Infusion [i.v.] 3-methylindole (3MI) induced acute pulmonary edema in goats. Edematous changes were seen in the alveoli and the interalveolar interstitium. At 72 h after treatment, an accumulation of glycogen that had a pathognomonic appearance of alpha particles was observed in the alveolar type II cells. A rich accumulation of glycogen particles and defective lamellar bodies containing triglycerides were the significant morphologic changes in the alveolar type II cells. Apparently, massive glycogen deposition in the alveolar type II cells is a defect that might interfere with surfactant production, further complicating the disease process.