ANTIHYPERTENSIVE ACTIVITY OF A PROPRANOLOL ANALOG (ORF 12,592) IN RODENTS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 224  (1) , 102-108
Abstract
Studies were carried out to determine the antihypertensive effects of the 5-hydroxy derivative (ORF 12,592; [1-(5-hydroxy-1-naphthoxy)-3-isopropylamino-2-propanol HCl]) of propranolol. Acute administration to ORF 12,592 produced a reduction in mean systolic blood pressure in desoxycorticosterone acetate (DOCA) rats and in spontaneously hypertensive rats (SHR). Propranolol was not effective in DOCA rats and produced a significant blood pressure reduction in SHR 48 h after acute administration. The antihypertensive activity of an analog of propranolol, was demonstrated and the concept that the antihypertensive effects of propranolol may be mediated through a metabolite was supported.

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