Kinetics of osmotically controlled indomethacin delivery systems after repeated dosing
- 1 August 1982
- journal article
- research article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 32 (2) , 270-276
- https://doi.org/10.1038/clpt.1982.158
Abstract
Two osmotically driven, controlled-release dosage forms of indomethacin [an antiinflammatory agent] were evaluated in a multiple-dose crossover study in 12 healthy subjects. Following equivalent daily doses, less frequent dosing of both controlled-release forms resulted in plasma concentration profiles that are more uniform than those following capsule regimens. After the 1st day, morning predose plasma levels were significantly higher for the controlled-release treatments. Renal clearances were similar between days and among treatments. Total urinary recoveries were comparable for all regimens.This publication has 1 reference indexed in Scilit:
- A power study of a rank transform for the two‐way classification model when interaction may be presentThe Canadian Journal of Statistics / La Revue Canadienne de Statistique, 1974