Serum Prolactin after Chest Wall Surgery: Elevated Levels after Mastectomy

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Abstract
Galactorrhea is a recognized sequel of chest injury, but serum PRL [prolactin] levels in these patients were not systematically documented. The PRL responses over 5 days in patients undergoing either mastectomy (10 patients) or thoracotomy (10) and in 7 patients undergoing elective laparotomy (controls) were examined. Basal serum PRL levels were normal in every subject. There were no consistent or significant alterations in PRL levels after laparotomy or thoracotomy. After mastectomy, PRL levels rose from a mean preoperative level of 7.1 .+-. 1.3 to 16.0 .+-. 3.3 ng/ml (P < 0.01) on the 1st postoperative day. Mean levels continued to rise to 35.6 .+-. 6.6 ng/ml (P < 0.005) on day 5; levels were supranormal in 8 subjects. Hyperprolactinemia persisted in the 4 subjects evaluated 4 wk postoperatively and in 1 of 5 patients evaluated at 6 mo. In a retrospective study, serum PRL levels were measured months to years after thoracotomy (31 patients) and mastectomy (53 patients) and compared to levels in 41 normal female controls. Mean serum PRL levels were 8.4 .+-. 1.3 ng/ml in the control group, 13.1 .+-. 0.9 ng/ml in the thoracotomy group (P < 0.005), and 20.6 .+-. 3.1 ng/ml in the mastectomy group (P < 0.001). One thoracotomy patient and 18 mastectomy patients (34%) had supranormal PRL levels. Mastectomy acutely stimulates PRL secretion in most subjects, and levels may remain elevated for months, perhaps for years, in a proportion of patients. Both the acute and chronic hyperprolactinemic states are probably the result of neurogenic PRL release mediated via the suckling reflex.

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