The Antibacterial Effect of Some Neuroleptics on Strains Isolated from Patients with Meningitis

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Abstract
Eighty‐two strains of bacteria (Neisseria meningitidis, Haemophilus influenzae, Enterobacteriaceae, Streptococcus pneumoniae, group B streptococci andListeria monocytogenes) were examined for theirin vitrosusceptibility to eight drugs, seven neuroleptics (perphenazine, fluphenazine, cis(Z)‐clopenthixol, haloperidol, clozapine, clebopride and SCH 23390), and the neuroleptically inactive trans(E)‐clopenthixol. The phenothiazines and the thioxanthenes were, on the whole, the most active drugs when measured, the IC5050for each group of bacteria being 7.4 to 84 mg/1 (with the exception of the activity against the enterobacteriaceae). The antibacterial potency of clozapine, which has an atypical neuroleptic profile, was between 50 and 140 mg/1. Haloperidol also showed an antibacterial activity in the concentration range 35‐140 mg/1. The selective D1antagonist, SCH 23390 and the selective D2antagonist, clebopride, inhibited only few of the bacteria in the concentration range investigated.