Functional Aortic Insufficiency — A Feature of Renal Failure

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Abstract
PRESENCE of an aortic diastolic murmur generally signifies organic valvular disease. Functional aortic insufficiency is unusual; its occasional occurrence has been attributed to such hemodynamic stresses as hypertension,1 2 3 congestive heart failure4 , 5 and anemia.6 We have noted, however, that the murmur is not an infrequent occurrence in patients with renal failure. These subjects often have some combination of hypertension, fluid overload and anemia and, therefore, present a clinical situation that favors the appearance of functional aortic insufficiency. It is important to recognize this entity in azotemic patients, to avoid erroneous diagnoses of organic valvular disease.MethodsIn a 45-month period 12 . . .

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