5'-RIBONUCLEOTIDES AS GUSTATORY STIMULI IN RATS ELECTROPHYSIOLOGICAL STUDIES

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Abstract
1. The chorda tympani responses to stimulation of the tongue of rats by Land D-MSG, 5'-GMP, 5'-IMP. 5'-UMP and 5'-CMP were recorded. 2. The 5'-ribonucleotides were found to produce a response in the chorda tympani nerve at a very low concentration and the response was characterized by its marked sustained phase. The stimulating effectiveness was in the order of L-MSG>D-MSG and 5'-GMP>5'-IMP>5'-UMP>5'-CMP. 3. A marked enhancement was observed in the response magnitude when a small amount of 5'-GMP or 5'-IMP was added to L-MSG or when a part of L-MSG was substituted for an equal amount of 5'-GMP or 5'IMP. 4. Similar enhancement, though small, was observed in the response magnitude when 5'-UMP or 5'-CMP was added to L-MSG. 5. No enhancement in the response magnitude was obtained either when 5-GMP and 5'-IMP were mixed together or when 5'-IMP or 5'-GMP was mixed with 5'-UMP or 5'-CMP.

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