Effect of α-Methyldopa on the Pulmonary Vascular Changes Induced by Chronic Hypoxia in Rats
- 1 October 1977
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 53 (4) , 397-400
- https://doi.org/10.1042/cs0530397
Abstract
Groups of young rats were kept in a hypoxic chamber or in air as control animals for 28 days. Hypoxic and control animals were treated with .alpha.-methyl-3,4-dihydroxyphenylalanine (.alpha.-methyldopa) or distilled water. .alpha.-Methyldopa significantly reduced increase in pulmonary artery pressure and right ventricular hypertrophy induced by chronic hypoxia and partially prevented histological changes in small pulmonary vessels.This publication has 3 references indexed in Scilit:
- Resolution of Hypoxic Changes in the Heart and Pulmonary Arterioles of Rats during Intermittent Correction of HypoxiaClinical Science, 1977
- Inhibition of endotoxin-induced pulmonary vasoconstriction in dogs by alpha-methyl dopaAmerican Journal of Physiology-Legacy Content, 1963
- SOME BIOCHEMICAL EFFECTS OF ALPHA-METHYL-3,4-DIHYDROXYPHENYLALANINE AND RELATED COMPOUNDS IN MICE1961