Neonatal Immune Thrombocytopenia — The Doctor's Dilemma

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Abstract
Idiopathic thrombocytopenic purpura (ITP) is a relatively uncommon disorder that has a predilection for women of childbearing age. In fact, a clue to the possible immune nature of ITP came from the observation that many women with ITP bear children with transient thrombocytopenia. The possibility of transplacental passage of antibody prompted Harrington to infuse plasma from patients with ITP into several normal recipients, including himself, thus inducing profound thrombocytopenia.1 This frequently cited study is a classic example of a pioneering clinical experiment that placed ITP on the growing list of antibody-mediated diseases. The Harrington experiments were quickly repeated, and the . . .