Administration of a Peptide Inhibitor of α4-Integrin Inhibits the Development of Experimental Autoimmune Uveitis

Abstract
Purpose. Recruitment of lymphocytes into the retina and to the vitreous during the development of experimental autoimmune uveitis (EAU) is governed by factors such as the state of activation of inflammatory cells and the repertoire of adhesion molecules expressed by the local vascular endothelia. α4 Integrins and their receptors play an important role during homing of cells to the inflammatory site. In the present study, the effect of α4-integrin inhibitor on the development of EAU was investigated.

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