THE BIOLOGICAL-ACTIVITY AND IMMUNOTHERAPEUTIC PROPERTIES OF AS-101, A SYNTHETIC ORGANOTELLURIUM COMPOUND

  • 1 May 1988
    • journal article
    • research article
    • Vol. 7  (3) , 163-168
Abstract
AS-101 (ammonium trichloro[dioxoethylene-O,O''-]tellurate) is a newly developed synthetic compound with immunomodulating properties and minimal toxicity. We evaluated the effects of AS-101 on various parameters of the activation and function of immunocompetent cells. AS-101 induced IL-2 receptor expression, IL-2 production and proliferation by human and mouse lymphocytes in vitro and enhanced the production colony-stimulating factor (CSF) by mouse spleen cells. In vivo treatment of Balb/c mice with AS-101 caused a significantly increased production of IL-2 and CSF in vitro in the presence of mitogen. When administered systemically to mice, AS-101 mediated antitumor effects in vivo. These results suggest that AS-101 is an active biological response modifier, which might have potential use in the treatment of conditions such as malignancy, AIDS and some types of immune deficiency.

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