A comparison of the anti-anaphylactic properties of ethanolamine and hydrocortisone

Publisher Website
Google Scholar
Abstract
Both ethanolamine and hydrocortisone potentiate the anti-anaphylactic activity of mepyramine in actively sensitised guinea-pigs subjected to anaphylactic shock by exposure to aerosols of antigen solution. The effects of these two substances have now been compared. After intramuscular injection, the peak effect with ethanolamine occurred 1 hr later whereas with hydrocortisone it occurred 18 hr later. Both substances were also effective, after 45 min and 12 hr respectively, as aerosols. The optimum intramuscular dose of ethanolamine was 10 mg/kg and that of hydrocortisone 100 mg/kg. After aerosol administration, optimum effects were observed when 5% solutions of either drug were used.