Increase in Capillary Filtration Rate Resulting from Reduction in the Intravascular Calcium Ion‐Concentration

Publisher Website
Google Scholar
Abstract
Nicolaysen, G. Increase in capillary filtration rate resulting from reduction in the intravascular calcium ion‐concentration. Acta physiol. scand. 1971. 81. 517–527.Marked reductions in intravascular concentrations of Ca++ and Mg++ has previously been shown to cause edema development. The effect of moderate reductions in the intra‐vascular concentration of Ca++ on the net rate of filtration from a vascular bed during increased capillary pressure has been analyzed. Isolated, ventilated rabbit lungs were perfused with plasma at 2° C. In each preparation repeated filtration tests were performed by standardized increases in the outflow pressure lasting for 6 or 10 min. The rate of weight increase for the preparation when 4 min of a test had elapsed was taken as the net rate of filtration. This net rate of filtration was shown to be increased when the [Ca++] was reduced to about 0.1 mM. This increase in filtration rate could be reversed by Ca++‐addition, but not by Mg++‐addition. Evidence is presented that this increase in filtration rate was due to changes in the “hydraulic conductivity” of the capillary wall.