Taurine Conjugation in Metabolism of 3-Phenoxybenzoic Acid and the Pyrethroid Insecticide Cypermethrin in Mouse
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 8 (9) , 565-571
- https://doi.org/10.3109/00498257809061256
Abstract
1. A substantial proportion of the radioactivity of an oral dose (1-20 mg/kg) of 3-phenoxy[14C]benzoic acid and the pyrethroid insecticide trans- and cis-[aryl-14C]cypermethrin (an α-cyano-3-phenoxybenzyl ester) is eliminated rapidly in urine of mice. 2. The major urinary metabolite of these compounds in two strains of mice is N-(3-phenoxybenzoyl)taurine. 3. Neither 3-phenoxybenzoic acid nor cypermethrin gives a taurine conjugate in rats. 4. Benzoic acid gives no taurine conjugate in mice.This publication has 14 references indexed in Scilit:
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