Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I
Open Access
- 1 December 2002
- journal article
- research article
- Published by Springer Nature in EMBO Reports
- Vol. 3 (12) , 1181-1187
- https://doi.org/10.1093/embo-reports/kvf238
Abstract
The scavenger receptor class B type I (SR‐BI), which mediates selective cellular cholesterol uptake from high‐density lipoproteins (HDLs), plays a key role in reverse cholesterol transport. The orphan nuclear receptor liver receptor homolog 1 (LRH‐1) and SR‐BI are co‐expressed in liver and ovary, suggesting that LRH‐1 might control the expression of SR‐BI in these tissues. LRH‐1 induces human and mouse SR‐BI promoter activity by binding to an LRH‐1 response element in the promoter. Retroviral expression of LRH‐1 robustly induces SR‐BI, an effect associated with histone H3 acetylation on the SR‐BI promoter. The decrease in SR‐BI mRNA levels in livers of LRH‐1+/− animals provides in vivo evidence that LRH‐1 regulates SR‐BI expression. Our data demonstrate that SR‐BI is an LRH‐1 target gene and underscore the pivotal role of LRH‐1 in reverse cholesterol transport.Keywords
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