Indirect atomic absorption spectrometric determination of sulphonamides in pharmaceutical preparations and urine by continuous precipitation
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of Analytical Atomic Spectrometry
- Vol. 3 (5) , 725-729
- https://doi.org/10.1039/ja9880300725
Abstract
Two atomic absorption spectrometric methods are proposed for the determination of sulphonamides in pharmaceutical preparations, based on continuous precipitation with copper and silver ions in a flow injection manifold. The precipitate is formed by injecting the cation into a carrier containing the sample and is subsequently retained on a stainless-steel filter. Various filters of different chamber inner volume, pore size and filtration areas were tested. By continuous precipitation, sulphonamides can be determined in the range 2.5–35 µg ml–1, with a relative standard deviation between 1.5 and 3% and a sampling frequency of 100–150 h–1. The copper method is more selective than the silver method and can be applied to the determination of sulphonamides in urine.Keywords
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