Can colonic bacterial metabolites predispose to cholesterol gall stones?
- 22 February 1975
- Vol. 1 (5955) , 438-440
- https://doi.org/10.1136/bmj.1.5955.438
Abstract
The cholesterol content of biliary lipids increased significantly when 16 healthy volunteers ingested deoxycholic acid (DC) for two weeks in a daily dose of 100-150 mg. Serum cholesterol also fell significantly to 88% of the baseline levels. Since DC is formed in the colon we suggest that populations in whom there is a high colonic absorption of bacterially metabolized cholate--that is, DC--have an increased predisposition to cholesterol gall stones.Keywords
This publication has 28 references indexed in Scilit:
- Biliary lipid outputs in young women with cholesterol gallstonesMetabolism, 1974
- Bile salt metabolism in patients with gallstones in functioning gallbladdersGut, 1973
- BILIARY LIPID SECRETION IN GALLSTONE PATIENTSThe Lancet, 1973
- The Epidemiology of Gallstones and Suggested AetiologyClinics in Gastroenterology, 1973
- Dietary fibre.Gut, 1973
- Bile acids, liver injury, and liver disease.1972
- The role of bile acids in the overall regulation of steroid metabolism.1972
- Bile Composition, Bile Salt Metabolism and GallstonesArchives of internal medicine (1960), 1972
- BACTERIA AND qTIOLOGY OF CANCER OF LARGE BOWELThe Lancet, 1971
- A statistical survey of the composition of gallstones in eight countriesGut, 1971