Renal Function in Preterm Infants during the First Five Days of Life: Influence of Maturation and Early Colloid Treatment

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Abstract
We measured the influence of maturation and early freshly frozen plasma infusion (FFP) on renal function (day 2 and day 5) in preterm infants in intensive care; they were divided into two groups, those with gestational ages < 30 weeks (G < 30) and those with gestational ages of 30–34 weeks (G 30–34). A total of 35 infants was studied. The infants were randomly assigned to one of two treatment groups, one receiving FFP, the other not, yielding four study groups; G < 30 and no FFP (8 infants), G < 30 and FFP (8 infants), G 30–34 and no FFP (9 infants) and G 30–34 and FFP (10 infants). The infants in the two FFP groups received FFP 10 ml/kg on days 1–3. FFP did not significantly influence creatinine clearance (Ccr) or the urinary sodium excretion rate either in G < 30 or G 30–34. CCr was significantly lower (p < 0.001) and fractional urinary sodium excretion significantly higher (p < 0.002) in infants of G < 30 than in infants of G 30–34. Infants of G < 30 had significantly higher plasma potassium concentrations (p < 0.01) than infants of G 30–34. Despite the low CCr and the high urinary sodium excretion rate, infants of G < 30 had stable fluid and electrolyte balance.

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