Genetic Models of Affective Disorder: Application to Twin Data
- 1 October 1980
- journal article
- research article
- Published by Cambridge University Press (CUP) in Acta geneticae medicae et gemellologiae: twin research
- Vol. 29 (4) , 289-294
- https://doi.org/10.1017/s0001566000007807
Abstract
Twin data on bipolar and unipolar affective disorders are analyzed by multiple threshold models of inheritance. The two illness types are represented in the models on a continuum of genetic–environmental liability in which bipolar illness has a higher liability threshold than unipolar disorder. Autosomal single major locus model provides an acceptable fit to observed concordance rates in monozygotic twins. The multifactorial-polygenic model is rejected.Keywords
This publication has 11 references indexed in Scilit:
- The use of multiple thresholds and segregation analysis in analyzing the phenotypic heterogeneity of multifactorial traitsAnnals of Human Genetics, 1979
- Adoption study supporting genetic transmission in manic–depressive illnessNature, 1977
- A Danish Twin Study of Manic-Depressive DisordersThe British Journal of Psychiatry, 1977
- Genetic analyses of pyloric stenosis suggesting a specific maternal effect.Journal of Medical Genetics, 1976
- The inheritance of affective disorders: A review of data and of hypothesesBehavior Genetics, 1976
- Genetic models of the transmission of affective disordersJournal of Psychiatric Research, 1975
- The Multifactorial Model of Disease Transmission: I. Description of the Model and its use in PsychiatryThe British Journal of Psychiatry, 1975
- The use of multiple thresholds in determining the mode of transmission of semi‐continuous traits*Annals of Human Genetics, 1972
- Diagnostic Criteria for Use in Psychiatric ResearchArchives of General Psychiatry, 1972
- A General Model for the Genetic Analysis of Pedigree DataHuman Heredity, 1971