Angioleiomyoma within a histiocytoma

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Abstract
We report an angioleiomyoma developed within a cellular histiocytoma on the calf of a 77‐year‐old man. The lesion consisted of a spherical nodule with two well‐defined concentric areas. The outer circular area was a cellular histiocytoma and the inner central area consisted of an angioleiomyoma. Immunoperoxidase investigations for desmin demonstrated positivity in the angioleiomyoma, whereas the histiocytoma positivity in the angioleiomyoma, whereas the histiocytoma remained negative. Serial sections of the lesion failed to demonstrate a connection between the angioleiomyoma and a normal vein which could have been trapped by the histiocytoma. The angioleiomyoma may have originated from a vessel in the histiocytoma.

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