Specific and Nonspecific Cooperation Between M‐Locus‐Incompatible T and B Cells During Adoptive Anti‐Hapten Antibody Responses in Mice

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Abstract
CBA and AKR mice are identical at the major histocompatibility locus (H-2) but differ at the strong, non-H-2, mixed leukocyte culture (MLC)-stimulating M-locus. Adoptive secondary in vivo antibody responses using immune spleen cells from mice of these strains demonstrate 2 findings. One is a non-specific augmentation of the anti-hapen [dinitrophenol] antibody response of CBA B [bone marrow-derived] cells by AKR T [thymus-derived] cells. This allogeneic effect is unidirectional in the same sense as the MLC between cells from these 2 strains. The 2nd is that, despite an ongoing allogeneic effect, M-locus-incompatible T and B cells show strong specific cooperation. It seems unlikely that the failure of H-2-incompatible T and B cells to collaborate specifically is due to inhibitory allogenic reactions.