Genome Analysis and Reverse Transcriptase Activity of Human Teratocarcinoma-derived Retroviruses
- 1 November 1987
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 68 (11) , 2807-2815
- https://doi.org/10.1099/0022-1317-68-11-2807
Abstract
Five of five human teratocarcinomas cultured in vitro could be induced to synthesize retrovirus-like particles, albeit in extremely low amounts. The accumulation and purification of the human teratocarcinoma-derived retrovirus (HTDV) from one of these cell lines allowed characterization of its genomic material as high mol. wt. (60S) RNA. Partial purification of HTDV-associated RNA-dependent DNA polymerase (reverse transcriptase) has also been achieved. HTDVs are easily distinguishable from the exogenous human T-lymphotropic viruses and human immunodeficiency viruses by morphological, biological and immunological criteria.This publication has 20 references indexed in Scilit:
- Adsorptive endocytosis of Semliki Forest virusJournal of Molecular Biology, 1980
- Specificity of human antibodies to oncovirus glycoproteins: recognition of antigen by natural antibodies directed against carbohydrate structures.Proceedings of the National Academy of Sciences, 1980
- Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus.Proceedings of the National Academy of Sciences, 1980
- DNA polymerases of normal and neoplastic mammalian cellsBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1978
- Human antibodies reactive with purified envelope antigens of primate type C tumor viruses.Proceedings of the National Academy of Sciences, 1978
- Properties of Mouse Leukemia Viruses X V . Electron Microscopic Studies on the Organization of Friend Leukemia Virus and Other Mammalian C-Type VirusesZeitschrift für Naturforschung C, 1978
- Virus infection of murine teratocarcinoma stem cell linesCell, 1977
- Virus-Like Particles in Placentas From Normal Individuals and Patients With Systemic Lupus Erythematosus 2JNCI Journal of the National Cancer Institute, 1977
- Natural human antibodies reactive with primate type-C viral antigens.Proceedings of the National Academy of Sciences, 1977
- New Human Tumor Cell LinesPublished by Springer Nature ,1975