Renin and Antirenin in Treatment of Long Term Experimental Renal Hypertension in the Dog.

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Abstract
Courses of intramuscular injections of semipurified hog renin from cortex given to dogs with experimental renal hypertensions of 4 or more years duration produced a significant reduction in blood pressure in those dogs which developed antirenin but not to normotension. Passive immunization with homologous antirenin to hog renin produced a reduction in blood pressure to normotension or near normotension in dogs with experimental renal hypertensions of more than 7 years duration. Results indicate that renin (or a closely related renal protein) is the principal pathogenetic factor even in experimental renal hypertension of many years duration in the dog.