Synthesis and Biological Activities of Some New 5′-Substituted S-Adenosylhomocysteine Analogues∗
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 2 (1) , 21-31
- https://doi.org/10.1080/07328318308078846
Abstract
The synthesis of new S-adenosyl-homocysteine (SAH) analogues substituted at the 5′-position is described. Their activity on cell transformation induced by Rous sarcoma virus (RSV) as well as their effect on cell growth and on replication of polyoma virus were also studied. The best results were obtained with compounds having a phenyl group at the 5′-position of adenosine. These molecules inhibit very strongly uridine uptake by cells.This publication has 11 references indexed in Scilit:
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