Structure Investigations on Products from the Reaction of Organocopper, Organolithium and Organomagnesium Reagents with 2(1H)-Pyrimidinones.
- 1 January 1985
- journal article
- research article
- Published by Danish Chemical Society in Acta Chemica Scandinavica
- Vol. 39b (6) , 459-468
- https://doi.org/10.3891/acta.chem.scand.39b-0459
Abstract
Alkyl- and arylcuprates and alkyl- and aryllithium and -magnesium reagents form 3,4- or/and 3,6-adducts with 1-benzyl-2(1H)-pyrimidinones. The effect of 5-halo substituents on the reactivity and regioselectivity is reported. Structure analyses were made by NMR spectroscopy. Dehydrogenation gives the conjugated, substituted pyrimidinones. X-Ray crystallographic data for 1-benzyl-5-chloro-4-phenyl-2(1H)-pyrimidinone and its regioisomer 1-benzyl-5-chloro-6-phenyl-2(1H)-pyrimidinone are discussed.This publication has 2 references indexed in Scilit:
- Pyrimidones 1. Synthesis of some 1‐substituted‐5‐aryl‐ and (4,5‐diaryl)‐2(1H)pyrimidonesJournal of Heterocyclic Chemistry, 1979
- Crystal Structure of Ribosylpyrimidin-2-one Dihydrate.Acta Chemica Scandinavica, 1978