Patterns of Brain Atrophy That Differentiate Corticobasal Degeneration Syndrome From Progressive Supranuclear Palsy

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Abstract
The corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP) are genetically related but pathologically distinct causes of progressive motor dysfunction and dementia. Because both diseases cause atypical parkinsonism that is not responsive to levodopa treatment, PSP and CBDS may be confused during life.1 As new therapies are developed to treat tauopathies such as CBDS and PSP, improved methods of antemortem diagnosis will be necessary to effectively target treatments to those individuals who are most likely to benefit.