Modified Smear Method for Screening Potential Inhibitors of Platelet Aggregation from Plant Sources
- 1 May 1985
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 48 (3) , 363-370
- https://doi.org/10.1021/np50039a003
Abstract
The smear method developed by Velaskar and Chitre was modified to allow the massive screening of plant extracts and/or fractions for platelet antiaggregating activity. Aspirin and papaverine, known inhibitors of platelet aggregation, were tested by the modified method and showed comparable results with previously reported data. Fifty-four fractions prepared from 18 plant species were screened for their inhibitory effects on ADP, arachidonic acid or collagen-induced rat platelet aggregation. Plants could be a potential source of inhibitors of platelet aggregation.This publication has 6 references indexed in Scilit:
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