Reversal of fungitoxicity of 8-quinolinols and their copper (II) bischelates. I. Amino acids and related compounds

Abstract
The effect of amino acids and related compounds on the toxicity of 8-quinolinols and their copper(II) bischelates to Aspergillus oryzae (ATCC 1011) was studied. None of the compounds tested except the thiol-containing compounds cysteine, cysteamine, glutathione, and N-acetylcysteine reversed the inhibitory action of 8-quinolinol but not that of 5-iodo-8-quinolinol or bis(8-quinolinolato)copper(II). It appears that the mechanism(s) of fungitoxicity of 8-quinolinol is different from that of 5-iodo-8-quinolinol or bis(8-quinolinolato)copper(II).

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