The Trypanocidal Effect of Nucleocidin In vivo

Abstract
A new antibiotic, nucleocidin, was tested for trypanocidal activity against Trypanosoma congolense, T. equinum, and T. gambiense. Three daily doses totaling 0.15 mg/kg produced approximately 95% cures in rats and mice infected with T. congolense, 91% in mice infected with T. equinum, and 73% in mice infected with T. gambiense. This is the first report of an antibiotic highly active against T. congolense.

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