Characterization of somatostatin release from the pancreas: the role of potassium

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Abstract
The effect of K on somatostatin secretin from the isolated perfused canine pancreas was studied. K stimulated dose-dependent somatostatin release in a monophasic response pattern. The effect of K was abolished in the absence of Ca. Perfusion of 1 .mu.M atropine and 1 .mu.M propranolol was without effect on the K-induced somatostatin release. The stimulatory effect of K on somatostatin release is secondary to increases in Ca influx into the D cell. The sympathetic and parasympathetic nerve endings in the pancreas are apparently not involved in the K mediated secretory processes.