Effect of Hypoxia on the Metabolic Response to Cold

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Abstract
O2 consumption rates, minute volumes of respiration, respiratory quotients and rectal temps. of 4 normal trained unanesthetized dogs were measured in a warm environment (ambient temp. 24 0C) and a cool environment (temp. 12 0C) during a prehypoxic period (breathing air) followed by a 1-hr. hypoxic period (breathing O2-N2 mixtures varying from 8-16% O2), and followed in turn by a post-hypoxic air-breathing period. O2 consumption rate fell early in the hypoxic period but rose to above prehypoxic values later in the period. RQ rose early in the hypoxic period to a peak value, falling later in the hypoxic period. In the cold environment the RQ peak was lower than in the warm environment, and when breathing 8% O2 in the cold there was no peak. Respiratory min. vomume was stimulated both by cold and hypoxia. Rectal temps. fell almost at the same rate in a cold and a warm environment for breathing mixtures of 20.9, 16 and 18% O2. For breathing mixtures of 12% O2, the rectal temp. fell faster in a warmer than a cold environment.

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