Does Insulin Play a Role in the Regulation of its Own Secretion?

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Abstract
Inhibition of insulin secretion by exogenous insulin which depends upon the mode of glucose stimulation, the relation of time between insulin and dextrose application and insulin infusion rate were studied in the human. Fifty microunits immunoreactive insulin per ml given by insulin infusion were sufficient to cause inhibition at fasting blood glucose concentrations. Regulation of insulin secretion by feedback inhibition is of physiological importance.